Skip to main content
SearchLoginLogin or Signup

Review 1: "Nasally-delivered interferon-λ protects mice against upper and lower respiratory tract infection of SARS-CoV-2 variants including Omicron"

This preprint examines the role of interferon-λ (IFN-L) in providing protection against COVID-19 using mouse model systems. Reviewers found the main claims of the paper reliable, with findings informative for future evaluation of IFN-L treatment’s efficacy in COVID-19 patients.

Published onFeb 21, 2022
Review 1: "Nasally-delivered interferon-λ protects mice against upper and lower respiratory tract infection of SARS-CoV-2 variants including Omicron"
1 of 2
key-enterThis Pub is a Review of
Nasally-delivered interferon-λ protects mice against upper and lower respiratory tract infection of SARS-CoV-2 variants including Omicron
Description

SUMMARYAlthough vaccines and monoclonal antibody countermeasures have reduced the morbidity and mortality associated with SARS-CoV-2 infection, variants with constellations of mutations in the spike gene threaten their efficacy. Accordingly, antiviral interventions that are resistant to further virus evolution are needed. The host-derived cytokine IFN-λ has been proposed as a possible treatment based on correlative studies in human COVID-19 patients. Here, we show IFN-λ protects against SARS-CoV-2 B.1.351 (Beta) and B.1.1.529 (Omicron)variants in three strains of conventional and human ACE2 transgenic mice. Prophylaxis or therapy with nasally-delivered IFN-λ2 limited infection of historical or variant (B.1.351 and B.1.1.529) SARS-CoV-2 strains in the upper and lower respiratory tracts without causing excessive inflammation. In the lung, IFN-λ was produced preferentially in epithelial cells and acted on radio-resistant cells to protect against of SARS-CoV-2 infection. Thus, inhaled IFN-λ may have promise as a treatment for evolving SARS-CoV-2 variants that develop resistance to antibody-based countermeasures.

RR:C19 Evidence Scale rating by reviewer:

  • Reliable. The main study claims are generally justified by its methods and data. The results and conclusions are likely to be similar to the hypothetical ideal study. There are some minor caveats or limitations, but they would/do not change the major claims of the study. The study provides sufficient strength of evidence on its own that its main claims should be considered actionable, with some room for future revision.

***************************************

Review:

The subject of this study is important and interesting. The authors have provided a beneficial dataset and information about the protective role of interferon-λ against SARS-CoV-2 infection using cutting-edge methodology. The manuscript is well-written and well-organized. In my opinion, a shortcoming of this manuscript is the lack of data about side effects of interferon therapy regarding liver injury and changes in liver enzymes i.e. aspartate transaminase (AST) and/or alanine aminotransferase (ALT).

According to the findings of the present study, interferon-λ can reduce viral load. Reducing viral load can decrease the disease severity. A study by Aiolfi et al.( https://doi.org/10.1182/blood-2021-148713) has demonstrated that clinical features characterizing severe COVID-19 cases, including inflammation and thrombosis, can be observed in K18 hACE2 transgenic mice. This mouse model has been used in the present study. I wonder if the authors have collected any data about reducing the virus load using interferon-λ and its relationship with clinical features of severe COVID-19 such as thrombosis.

The authors correctly referred to the limitations of their study. Although their findings are valuable, it is not clear to which extent their results may be related to COVID-19 patients. For instance, in the present study, the interval between virus inoculation and interferon injection is clear, while in COVID-19 patients, the time point of infection is not clear. While more investigations are needed to answer these questions, the present study has provided useful information about interferon-λ as a possible treatment for COVID-19 patients.

Comments
1
Vape Factory:

https://vape.flyah.co/

https://www.craft.do/s/pGHl64BQNkG81l

https://app.pandadoc.com/document/ccbbb181d3970df0e159ae0db5bda1ce006b9684

https://typed.do/d/1TvxFfjRZqFeeYSHV6bfYC

https://coda.io/d/Meet-Coda_dHUrYkVP50q/Recommended-E-cigarette-Ranking_suRD8

https://gamma.app/public/55vw7v7cwdpzl84

https://www.taskade.com/d/YqF4axe2xCqW9cVQ?share=edit&edit=EERAydoeC9ewVw7k&as=list

https://documenter.getpostman.com/view/24696379/2s8Z6vXZEe

https://postheaven.net/vapecig/

https://postheaven.net/vapecig/about-the-vapor-from-the-e-cigarette

https://postheaven.net/vapecig/how-to-use-a-disposable-vape

https://postheaven.net/vapecig/what-is-a-disposable-vape

https://postheaven.net/vapecig/how-to-recharge-a-disposable-vape

https://postheaven.net/vapecig/what-is-the-best-disposable-vape

https://demo.writefreely.host/vapecig/

https://demo.writefreely.host/vapecig/how-to-charge-disposable-vape

https://demo.writefreely.host/vapecig/why-does-my-disposable-vape-taste-burnt

https://writee.org/vapecig/

https://writee.org/vapecig/why-does-my-disposable-vape-taste-burnt

https://writee.org/vapecig/how-to-fix-a-burnt-disposable-vape

https://vapecig.take.app/

https://pocketnotes.app/note/kXCc6hy

https://telescope.ac/vapelife/

https://telescope.ac/vapelife/zxkvsndompo0u4elvx9lyc

https://telescope.ac/vapelife/1rx7w1ejtw0qvt3ro23u51

https://penzu.com/p/8bc8364c

https://penzu.com/p/65558e82

https://www.lesswrong.com/posts/eNDdhtKGSBmukLHLk/do-e-cigarettes-help-you-quit-smoking

https://zenwriting.net/vapecig/what-happened-to-the-issue-of-vape-regulation-in-the-u-s

https://writeablog.net/vapecig/what-happened-to-the-issue-of-vape-regulation-in-the-u-s

https://writeablog.net/vapecig/what-are-the-benefits-of-disposable-vapes

https://telegra.ph/People-who-are-addicted-to-electronic-cigarettes-08-27

https://telegra.ph/The-difference-between-shisha-and-vape-11-30

https://graph.org/How-many-cigarettes-is-600-puffs-02-01

https://graph.org/Can-I-Sell-Vapes-on-Amazon-02-01

https://th.hashi.icu/vapecig/what-is-a-vape

https://th.hashi.icu/vapecig/what-is-a-vape-967m

https://posteezy.com/about-vape-device

https://notepin.co/vape/

https://vape.notepin.co/about-the-vape-device--it-is-necessary-to-have-bf4ggmd

https://mypost.io/post/about-the-vape-device

https://editor.telescope.ac/blogs/vape/h25r8e62kw2jck0d81rthk

https://editor.telescope.ac/blogs/vape/zdxgq0jirl8c99qeznywls

https://theprose.com/post/545986/lets-get-the-basics-of-vape

https://theprose.com/post/612492/is-smoke-and-vape-shop-a-good-investment

https://mydukaan.io/vapestore3+A478:A505/blog/is-disposable-vape-healthy

https://mydukaan.io/vapestore3/blog/is-vaping-cheaper-than-smoking

https://mydukaan.io/vapestore3/blog/what's-the-healthiest-vape

https://skincare.gonevis.com/some-popular-e-cigarette-recommendations/

https://skincare.gonevis.com/how-to-choose-an-e-cigarette-2/

https://vapecignew.livejournal.com/503.html

https://homment.com/l1H5OHVjZXcDaq4Ybk4k

https://homment.com/CccIJaMfDxyuavggDqCy

https://homment.com/dZUvwY6XFK8PSo0jMIx6

https://homment.com/FSBeuS017ZjfSAMYR8Xa

https://slides.com/vapecig/vape

https://ecigator.contently.com/

https://onlinehtmleditor.dev/collaboration/#doce8ef979a41

https://anotepad.com/notes/dcfn4meq

https://anotepad.com/notes/4mx5serm

https://warengo.com/stories/263598-the-difference-between-shisha-and-vape

https://www.townscript.com/e/ecigarette-explosive-smoking-132331

https://z4nd8shuds3.typeform.com/to/vbyiOkHz

https://form.jotform.com/223281115973051

https://www.beclass.com/rid=2748d1c6396e2900f09a

https://express.adobe.com/page/X42msE6GXamXo/

https://froont.com/vapecig/vape-factory

https://froont.com/vapecig

https://www.launchora.com/story/a-beginners-guide-to-using-disposable-vapes

https://www.edrawmind.com/online/map.html?sharecode=638112c84044b6a76907970

https://coggle.it/diagram/Y4SWT71Eo51jqWxN/t/disposable-vape-factory/2498349aba1ddbe2f049806185757f44da430ec1cdfe9d86a2a99829fcd81aef

https://onodo.org/visualizations/217139

https://bubbl.us/NzUxMzYyMC81MjIyMTUxLzAwMmE3YmIyYzVhNzE3OGYwOTFmM2VmZjFlNTk5YTc30

https://www.emoneyspace.com/vapfactory

https://vapefactory.straw.page

https://alchetron.com/Tron/Are-disposable-vapes-worth-it%3F-5208902-UW

https://qrcodes.pro/ROUaK5

https://jsitor.com/preview/t9QBmzn21A

https://paste.feed-the-beast.com/view/c871a9a5

http://paste.akingi.com/xXNQPm0b

https://paiza.io/projects/9LE_W0Gz_j91ZBld5tttMg

https://jsitor.com/preview/zXGhC2Drh6

https://ide.geeksforgeeks.org/online-html-editor/ebde2019-c99b-4042-aed5-46c30cf12371

https://www.pastery.net/fwfges+tauxjc/

https://justpaste.it/vapelinks

https://justpaste.it/disposvapes

https://pasteio.com/xeRbHgWXHjQb

http://pastebin.falz.net/2499501

https://paste.awesom.eu/raw/vapecig/TLWP

https://onlinegdb.com/I98N_Bx5qe

https://yamcode.com/hluokettws

https://yamcode.com/f2ihsedvzo

https://paste.toolforge.org/view/c553c2e4

https://notepad.pw/XxPEejtANAeqTKIk49SM

https://tempel.in/view/45b6a1f6

https://paste.gg/p/vapecig/a20000c50f844db3ad13198fe224b962

https://bitbin.it/0WfVktk9/

https://paste.opendev.org/show/818127/

https://pastebin.freepbx.org/view/0453a430

https://paste.cclinux.org/view/d96e5d47

http://pastebin.viradev.ir/pastebin/view/8f57f2c8

http://yatespost.com/view/70c8bf84

http://paste.vasiliy.pro/view/eb78dd64

https://paste.elyograg.org/view/1471f5fc

https://archive.ph/PuKik

https://note.vg/vape-35144

https://paste.zyrex.org/view/264bad6f

http://pastebin.loki.pitechnologies.ro/index.php/view/40824360

https://chris.teria.org/pastebin/view/2dfa0a30

http://minetest.wjake.com/stikked/view/a74ae71c

https://paste.tecnocratica.net/view/57f7e54e

https://paste.steamr.com/view/e4f62a61

http://stikked.luisaranguren.com/view/7010ba28

https://paste.artixlinux.org/view/a55b3ecd

https://paste.gajim.org/view/9045449c

https://paste.tunestiga.com/view/752f7666

http://paste.purplehat.org/view/72d8bc68

https://paste.unixkoans.com/view/bb4ffd74

http://stri1.rf.gd/view/91c5ca2d

https://jsfiddle.net/vapecig/ag2er6z7/

https://ideone.com/nP3WgL

https://controlc.com/0f24f515

https://pastelink.net/8qdpqmfc

https://pastelink.net/9km5gn49

https://rentry.co/vapefactory

https://dpaste.com/FUQXS76JF-preview

https://pastebin.com/04mkpDB3


https://notepadonline.co/share/70qmAs1669651083

https://pastefree.net/rWjydLk40qM

https://pastebin.freeswitch.org/view/9b57eed9#L4

https://paste.laravel.io/688daa1c-95be-4a23-91a1-416c1aa2a51c

https://privatebin.net/?7ee27902ae520446#5dmwsRS4W4fgfHTpS6A8nQo8mKyLHyMy35pLsdEFUg3D

https://0.0g.gg/?7226fa607132dcc8#4L7oTRLQAbKq4H4dCJKUCRamffi9aWAJZVsJqoLShYLz

https://0.jaegers.net/?d71fa6d60d16d9c4#7Ci3qwA6vzuK7ohDdPqTMkepkPewTYZeN2Z6dsvwf3y3

https://0.klowdee.host/?cc808aabc0dd0738#CYeEDv5hu2kxeXviC2Wwo7h8H5BGaYvHjed71nr65euA

https://0a0bin.klowdee.host/?f18fa4c110b9b729#3syGanFWJDhC2tT3ktbWmvMoz1B6kS4Nryc75gBP46aG

https://bin.0xfc.de/?04c4c9210605c990#2mNrfSFPSNiMhaBjnsv9oyjp1oUu6dm7iweJ7EgVETEL

https://bin.foss.wtf/?b27a17546ed2967f#59LVV9fiBsvGFvxbH2gstGYui8F9RUGqDCzo8SwRaHo4

https://bin.klowdee.host/?44fa044b95ec4ce8#3Cwx7MY9DQnr73jFyQRMtSEx7yAkoiPW3ZaSVMMVaVVa

https://cpaste.org/?b285fb0b8449f762#3eZGT84ufHHA8evrA7TiVD2XMqY33sGypqJKCtmsqAKi

https://luckvintage.com/?b6aa2187d87b5b5b#4MyEwLyQy3Vvf37jf8utvZ1NULhRq4ZxcvQniU9LcYJq

https://notebin.de/?b7de10af28186a8a#7HUVdbgJH9rbL46L8EECx5H4bk3MF1ui2QWwchBbSmzw

https://p.darklab.sh/?cf50217497eeae33#48HiHNt9GHoMeJGMUqE46j8UjfFhua3effjGt5h3qTjQ

https://kll.li/cw780

https://go.0xfc.de/s1a7r7

https://paste.hostux.net/?822a5f95af3db05d#4ZJRA66F7RUehyBWknzZpdxnGFFEW1Y66vLgp9pSL2Mc

https://paste.itefix.net/?cfc5e8027ceb23d9#4VZhAx7NzHAHKaoVY3DR3RJgzzWtgBwBuY1mAQ9qUeu7

https://paste.momobako.com/?b54710533275e10d#9hzSVLacr2GJvmkUdD2VNLSXfikJxdPgGo9FpsBmNMvJ

https://url.oelrichsgarcia.de/AMwB7

https://paste.ononoki.org/?6aac4bb7152ba76f#4rmak4Go7oUSessUpNtMccJGEiid6Axwuy4VaRCFPtVe

https://paste.ottertelecom.com/?ed368dcd2e0f3e4b#89hZMmJi3LTQyng5mm5J7uSq56TBUyoS9k7eLvzLAHvC

https://bhh.sh/6kv

https://justpaste.me/vapefactory

https://www.pastery.net/csjmje/

https://newtextdocument.com/t/vapefactory

https://www.zippyjot.com/note/88290

https://markdownpastebin.com/?id=a87386eca19e43daaceaed38cadd93c1

https://hastebin.com/quwaburiri.md

https://paste-bin.xyz/968218

https://nopaste.ml/?l=mrwn#XQAAAQDnAQAAAAAAAAAeHAPEVLS59lHh3xg/OQJcdvrR/U/ycPo2VIPTB2g5g8Xf3v9Di/NYf7K1aoBwxEWvaUiz2xGhkHA8Mp/R2IyT8KpMmUbNVcmHxITFXNsgKqIv1hRDigz47zJvZW3iGL85D2EuDE9cxVD+YLV2CLgxkDF+R7glyaaiV6Pm5MBJAholv6w3TKRjNhO0y7V2XJkEgSeu3rdXjPjBzz9F854nO7RKfQpgjv1PA+RqmQiWiZmAL3UkPJp33AEElJ/8phS+hzfLc6UMapKD/pqj6LGDJNZJi5aEsnIiMwQ29bychERkSJawkORymO/OB4m1EjdkbT30APJicH+7qzZiYocJ84TrgGIKr4gpRnbW1CGDhx67yhxlE+z/c40ZabsRx+uj8FShzQX8KxJcFVzDSctTm4SGT6ShtRah6HAXNEB5FJoXbH/9o8ml

https://snippet.host/egrzod

https://notes.io/q3CXc

http://paste.akingi.com/g5EEKUXr

http://paste.jp/2340b335/

https://pst.klgrth.io/paste/76vh9

https://paste.tuxcloud.net/?aa43b8a439474f4e#8wCMq5omoVJT9afkCsKEtMGdbS1MYYy8YbYP4sJbfKPc

https://pastebin.grey.pw/?eb7f9227f8f9c675#BkfKX9pm6vBGowxf6etgtp41kmKWQYmvqbTvdotFQe9b

https://pastebin.hot-chilli.net/?c4856edc9f75c3ec#DYE8CWiyRi9fvysdP9t5AriNnjbqtoWefMoRhGbhZt52

https://pastebin.linqhost.nl/?79e1ea7c8119baf6#7DnPowcnmoR32hKsT2MkMmvhycxuLnfyLuaktHw3rGR7

https://privatebin.at/?9f5afe906740f58a#AtuK5mpf5UNxDqwM7wVn6FQ3GCjA6fbC19zFhidfyjUE

https://privatebin.io/?0e28d362cd4ce612#J34S6ctSCh5HiZZGWUdpx36kyfHRqrh1KgJZPbqiookX

https://privatebin.net/?7f6bc481048e5b8b#3ZdBUUT2dS7Pk9sBsG9bkzJfm8Dk6BgemQttXGYiNy5W

https://privatebin.rockhost.se/?c1166fe766ea7487#DxwTJh5edJD4JCZhaFzH1U1i5NhsFF6tPBcDyYc9udBg

https://secrets.cebador.fr/?754c0492a4bdd103#DmzM2yiqtmpY95rxPhM8eso5KfRHU5FjhVBWqhsYYGEy

https://secrets.true.nl/?488ab298dcb02fce#4A2B7nEMMRN63WXAkUEY5LtoakxQXAUgNhkdZF93uts3

https://snip.dssr.ch/?0146ac45d8d6ffac#B8nkmXDzQqQ8f4gXWxzLXjduXWf8WFoPt3jRDkJ1pquW

https://zerobin.thican.net/?7fd683a533740ffa#Enwiu5mgU26Yp46DR4JKyDm32tcmKHhMM6UkWg55dqRq

https://u.07f.de/sbedo

https://6066.xyz/KY71C

https://paste.techbag.app/?bad2bb1088ef1781#4XDqEnMPuNywwKDvQscA3pNZr5Suyii8EUhfmYAdqwd9

https://bin.disroot.org/?34f408620dd08504#DX6rcUAGwMgiCZDCjbDNGFjPa1yWAtSiowgY3R6PyJSK

https://bin.garbaye.fr/?41119183d0c1484a#CAuUEi2dzYm28ZF9URukd44cf6aaBMmBWSAZmyANPBW3

https://bin.jae.fi/?dcd0702412de36ac#C1HKVZkhYzNhuqRSF9Hnho888kToK4GnzeYZb9UdWhW7

https://bin.namazso.eu/?6c3f328a0c069e1f#96Nz4xUEAJ3hzrgiCqojSS2RgEfV5RW19njnPAJHx3JQ

https://paste.4s3ti.net/?ef5fb8a0ffcbe709#EmcFKBWzYxdMvBJvJ8CPAJRDhCtSsLKszzaiftjjAM37

https://paste.copper.dedyn.io/?f52b421d6109b0cc#5fNmacCp72coPLdtz2faEr1aYjnpR4vmtrVHhfbhVEH2

https://paste.d-ku.de/?d07e085405265f7d#GRAdmq9uDjZXg5opCP3h36LTW5oAE1mZPpAFXUr89HVW

https://paste.dismail.de/?21b8d752e0dec48d#FUUzTPVYzxd3hBBdXHE4nc3F77mPAa7fai3gafY23c9d

https://paste.eccologic.net/?ab9d2f0462187994#5vjUsqhuGJshaPiscQwS4JvNfY72eta7fSrjmtJttxV2

https://paste.hackliberty.org/?a04ead16b6b8c312#4zpjbDFma7Miw2iVk8WqCYRGZazd12x72xU83rStsWZ

https://paste.rys.pw/?d1d4ac683b2f7e88#DmigSE23jeFfNkGN5RFu269CgYRGJV1Tt8QaGnyNnps6

https://paste.sethforprivacy.com/?1d6d069875eb2db9#9Nm4E7DNKKVh1b5SGboTgBnVBPCNRT2JaXiYqgTwNJfW

https://paste.systemli.org/?d90bc7e0a909554e#SGBUtKNVewU4VikTzYRyBkEXSWhGZCuVGbZ4hbN1TXn

https://paste.waays.fr/?aa425d0274bd796e#6DnyTu5mzV7pqjAkbyKe6X2S6HLTRjoXbceq34vhbVMG

https://pastebin.aquilenet.fr/?92de145104d2e458#4aFNoRvVpejtdq6Jna7ecdcJALMgbfYR5k27mvie66nA

http://pastebin.falz.net/2499575

https://0paste.com/436994

https://tech.io/snippet/p9dNUJz

https://tlabs.link/5awo1tf2

https://pastewith.me/?89fde2459aecba0e#7ynHu9kUBW1ABRvfSThfwKMkgu6eZeW8wofRdvrtsSB4

https://pb.fedi.tech/?894fbb8ba3003f76#HcnkPWzs5JbuXShSLLVvL7M2hWnHG2f5fpY4sH7Tn6y5

https://private.opendoor.fr/?9eb418f16baeb5c8#9HWLurWyxXZRnNEvaDTk415gZXUkdy5MM2GVbYJvESLU

https://private.rmconsulting.com/?f4594eab15556b7d#FX2rxTf4Ga1aFv1gnrBzpc4bmDwUzW8ngwVuFfqmXiGh

https://privatebin.jasonthai.me/?89793268fc239e37#8yUqzfKvpjX3NmV5LdquyVzS41nrfFECwfnYLEvJ6aSG

https://privatebin.jirlagun.com/?ec42065b71318070#8Q7oUK9QmsrRtnkDux8kJvX86PV3ArB2e8rS3DDMifYu

https://url.privatepastebin.com/1ad

https://pb.envs.net/?74f5d5a9bc465dbb#DsU4d7xfYnomPf31jCEPBQgzdmAkt5wHvsFxeykBBYJy

https://pastebin.24unix.net/?ad56dcbfa2d48988#8Ri45zN7FaTRHaLTkiFWNH3xC66n8AmrMoSFUZocYPqB

https://bin.byreqz.de/?e5a07954f69590d2#8fd1JscG5zQwFsj6dgaeSaCpL9HDGaWo41vpWsFDz56m

https://chobble.com/?814d9b4a4b1a7cef#sVZ7FYReqzh8J8NZkqjECvsxW8xM8EFkpia16NkWYpo

https://ots.ip-projects.de/?4556b6fe422e656d#EckKDsHfVcYZnTc1bvZXXWpHb8W9Ucx8TypADX8HupbA

https://p.ifxy.cc/?709fd4a770f0f9a1#2mY9t8Mkn5aNuwVMdi4y52MU3LakYS2VgtfdcPxzaHWq

https://paste.crabdance.com/?3be13ae9fe7ba44a#2K1KvTXTu3a5NnaxP4xCqm4hbUGU3rem9TyVdbtSUH2U

https://privatebin.lyndendoor.com/?6ab8deae13c2cfc7#7FD6rRqFteLMbJpLZifStLZCY4SvJYgaaJbSQNkKaaab

https://bin.acquia.com/?2ef0d31a8b9614c7#D8jEewoDsEcYUgPQtnALmtBV4wm5qFhR4g7zHTNhPyzH

https://pb.pc-sam.net/?40d680f27b67cbe2#pR1wspcNWWh9sZoteCHPQqRnP25SZJNKhowndZRpcPJ

https://bin.mycozy.space/?7a0fc665f69174a0#4jN5pUSx38GwGWiqEL6kVxNFdYD4vks9P4sKXWxYYXu7 

https://gitgd.com/?a7f84364b1b7b72e#7Rua3EQDiKziLC8fSkdZRoDBFEHstxY1qEsmTuU1xbAA

https://paste.cezeri.tech/?9148086a0f597547#FZmC95wNXmMspouQ31nkvqEZDa9M5Z6BDMzSRy2gEK13

https://paste.chapril.org/?1ad7ebf067dbed12#EV64GjoJdkz6wTiyvqLYEqunovXaZTZc6LGES5n8vD4t

https://paste.evolix.org/?0ee64a6e047f7768#2Zs8R3CNWzXysSGTRc2aqN4Hp4KdorHrL3BFmc5XUbiK

https://paste.ggc-project.de/?f9b94562a091fdfa#FbsV7UVc7vM2Q7ScoYDwNtbq2E1XUPmDs9hNLWs123Fk

https://paste.nolog.cz/?9313e29bc5d35fa7#38VHftE2hVz8KgjAv6uBWHAJkBHgST8sJKwooqHMbHwE

https://paste.ztn.sh/?b60f72c3aa63f186#5rHHdVqMwoLgsLYez5SvUn82sL9MM8hrRedbcA4MF9eS

https://pb.slipfox.xyz/?4925a178dc1214b1#CCr8N5eBwPmN5i2n7rrpEv5gej7qhB94NCM4orxme2Sr

https://postit.hadoly.fr/?a6fdd2be443110b7#F7mWqTyzJYzzcX3V95CDRy8h1QKAW7Femt2htEgE3Qp3